WebJul 23, 2024 · tsp-1为内源性血管生成抑制因子,内皮血管为主要分泌部位,生成后能够与cd36相结合,对新生血管形成过程起一定抑制作用,同时能够诱导内皮细胞的凋亡。 The thrombospondin-1 protein is a member of the thrombospondin family. It is a multi-domain matrix glycoprotein that has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. Both positive and negative modulation of endothelial cell adhesion, motility, and growth have been attributed to TSP1. This should not be surprising considering that TSP1 interacts with at least 12 cell adhesion receptors, including CD36, αv integrins, β1 integrins,
Antagonizing TSP1/CD36 Polypeptide Blocking the activation of …
WebAug 19, 2013 · It is known that CD36 interacts with TSP1 type 1 repeats. The residues of the CD36 molecule that specifically interact with TSP1 are referred to as the CD36 peptide … Web目的:探讨巨噬细胞表面分子凝血酶敏感蛋白1(tsp1)、cd36、cd47及其分泌细胞因子il-10和ifn-γ与原因不明复发性流产发病的关系.方法:采用流式细胞技术检测10例原因不明复发性流产患者和20例正常早孕妇女外周血及蜕膜巨噬细胞表面tsp1、cd36、cd47的表达; ... too much sauce bhandup
Thrombospondin 1 activates the macrophage Toll-like receptor 4 …
WebAug 1, 2024 · In this system, TSP-1 binding to CD36 was required for TGF-β activation and the authors suggest that TSP-1 represents a mechanism for controlling TGF-beta … WebOct 31, 2006 · Ligand for receptor CD36 (PubMed:1371676, PubMed:10613822, PubMed:11134179). Involved in inducing apoptosis in podocytes in response to elevated … WebTsp1+/+ thrombi was observed, but not of the Tsp1−/− thrombi. The roles of CD36 and TSP1 in thrombus formation were studied using Cd36 −/− blood, which was perfused over … too much salt in soil